DETERMINATION OF ANTIMICROBIAL ACTIVITY OF FRUITS OF CITRULLUS COLOCYNTHIS

Objective: The current study was designed to examine the antibacterial activity of various extracts Citrullus colocynthis fruits against Helicobacter pylori, Salmonella enterica, Shigella flexneri, Campylobacter jejuni, Micoplasma pneumonia, and dysenteriae.Methodology: Antimicrobial evaluated by agar disc diffusion method. available genome C. utilized retrieve sequence highly conserved genes matK, rpl20, rpl32, rps7 identify their relevant in rehmii.Results Conclusion: maximum antimicrobial shown ethanol extract (S. f. 32mm, j. 27mm, H. p. 26mm, S. d. 22mm, M. 21mm, e. 19mm) while least given n-hexane 13mm, 11mm, 18mm, 8mm, 10mm, 8mm) when compared with standard antibiotic levofloxacin 30mm, 28mm, 25mm, 20mm). All had response pylori flexneri pneumoniae enterica. in-silico genome-wide investigation studies showed that all four rehmii were identified high conservation based on motif distribution phylogenetic relations.